Clinical Study Title:
Preoperative oral B vitamins prevent nitrous oxide-induced postoperative plasma homocysteine increases.
|Plain English Summary:|
|The use of nitrous oxide has been associated with an increase in homocysteine levels of the blood. This study looked at the use of a b-vitamin complex during surgery involving nitrous oxide to help prevent the rise in homocysteine levels. A total of 53 patients who were undergoing elective surgery that lasted for less than 3 hours were enrolled. Participants were given a daily supplement of either a vitamin with folate, b6 and b12 or a placebo for a week prior to surgery. .Blood levels were measured before and during and after the surgery. Those participants who were using the b-vitamin complex did not have the increase in homocysteine levels that the other participants taking the placebo did. This supports the use of a daily b-vitamin supplement to help maintain the homocysteine levels in the blood during the use of nitrous oxide and other anesthesia.|