Vitamin K

With Warfarin.

Clinical Study Title:
Randomized, placebo-controlled trial of oral phytonadione for excessive anticoagulation.

Plain English Summary:
This study looked at the most effective way to treat anticoagulation associated with warfarin. A total of 30 participants with international normalized ratios (INR) that were above the norm were enrolled in this study. They were given either a vitamin K supplement or a placebo. Correction of the INR was achieved first in the group receiving the vitamin K supplement. The use of vitamin K as a supplement to warfarin therapy was more effective at reducing INR than just stopping the use of warfarin alone. This suggests always using a vitamin K supplement whenever using warfarin.
Patel RJ. Witt DM. Saseen JJ. Tillman DJ. Wilkinson DS.
Department of Clinical Pharmacy, Kaiser Permanente, Denver, Colorado, USA.
Country of Publication
United States
Pharmacotherapy. 20(10):1159-66, 2000 Oct.

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