Clinical Study Title:
A randomised placebo controlled exploratory study of vitamin B-12, lofepramine, and L-phenylalanine (the "Cari Loder regime") in the treatment of multiple sclerosis.

Plain English Summary:

This study looked at the use of a combination of drugs of lofepramine, L-phenylalanine and vitamin B12 in treating multiple sclerosis. Participants were enrolled from an outpatient clinic, and had to have been relapse free for 6 months. Participants were then given a combination of the drugs or a placebo. The results showed that the use of vitamin b12 helped to reduce pain and depression. Adding the lofepramine and L-phenylalanine helped to improve their condition further. The use of vitamin b12 can help to reduce the symptoms of multiple sclerosis and the disability of the disease.

Authors

Wade DT. Young CA. Chaudhuri KR. Davidson DL.

Institution

Oxford Centre for Enablement, Oxford, UK.

Country of Publication

England

Source

Journal of Neurology, Neurosurgery & Psychiatry. 73(3):246-9, 2002 Sep.