Clinical Study Title:
Phytomenadione or menadiol in the management of an elevated international normalized ratio

Plain English Summary:

This study looked at the effectiveness of an oral supplement of vitamin K versus an intravenous form of vitamin K for alleviating coagulopathies. Twenty-six patients with elevated international normalized ratio were given either the oral form or the IV form. The ratios were then measured over the next 3 days. Both methods were found to help to reduce the levels, but the oral supplements did not risk providing too much vitamin K, which can have adverse effects. This suggests that the oral form of vitamin K can be just as effective as the IV form.

Authors

Green B. Cairns S. Harvey R. Pettit M.

Institution

Royal Sussex County Hospital, Brighton, UK.

Country of Publication

England

Source

Alimentary Pharmacology & Therapeutics. 14(12):1685-9, 2000 Dec.