Clinical Study Title:
Randomized, placebo-controlled trial of oral phytonadione for excessive anticoagulation.

Plain English Summary:

This study looked at the most effective way to treat anticoagulation associated with warfarin. A total of 30 participants with international normalized ratios (INR) that were above the norm were enrolled in this study. They were given either a vitamin K supplement or a placebo. Correction of the INR was achieved first in the group receiving the vitamin K supplement. The use of vitamin K as a supplement to warfarin therapy was more effective at reducing INR than just stopping the use of warfarin alone. This suggests always using a vitamin K supplement whenever using warfarin.

Authors

Patel RJ. Witt DM. Saseen JJ. Tillman DJ. Wilkinson DS.

Institution

Department of Clinical Pharmacy, Kaiser Permanente, Denver, Colorado, USA.

Country of Publication

United States

Source

Pharmacotherapy. 20(10):1159-66, 2000 Oct.