Clinical Study Title:
Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial.

Plain English Summary:

This study examined the use of vitamin K supplements to treat coagulopathy associated with warfarin. Participants already receiving warfarin were given either an additional daily supplement of vitamin K or a placebo. The international normalized ratio was measured and compared across the two groups. Those patients who took the daily supplement of vitamin K had more improvement in their international normalized ratio than those taking the placebo. This suggests that the use of vitamin K with warfarin can help to control complications of treatment.

Authors

Crowther MA. Julian J. McCarty D. Douketis J. Kovacs M. Biagoni L. Schnurr T. McGinnis J. Gent M. Hirsh J. Ginsberg J.

Institution

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Country of Publication

England

Source

Lancet. 356(9241):1551-3, 2000 Nov 4.